2p1b Summary

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Crystal structure of human nucleophosmin-core

The structure was published by Lee, H.H., Kim, H.S., Kang, J.Y., et al., Lim, S.O., Jung, G., and Suh, S.W., in 2007 in a paper entitled "Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Nucleophosmin.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
B Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
C Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
D Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
E Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
F Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
G Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
H Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
I Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%
J Nucleophosmin P06748 (9-122) (NPM_HUMAN)search Homo sapienssearch < 90% 122 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06748 (9 - 122) Nucleophosmin Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J Jelly Rollssearch Nucleoplasminsearch

Chain ID Molecular function (GO)
A, B, C, D, E, F, G, H, I, J (P06748) nucleic acid bindingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J Nucleoplasminsearch Nucleoplasmin core domainsearch