2oza Summary

pdbe.org/2oza
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Structure of p38alpha complex

The structure was published by White, A., Pargellis, C.A., Studts, J.M., Werneburg, B.G., and Farmer II, B.T., in 2007 in a paper entitled "Molecular basis of MAPK-activated protein kinase 2:p38 assembly" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely MAP kinase-activated protein kinase 2 and Mitogen-activated protein kinase 14.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP kinase-activated protein kinase 2 P49137 (47-400) (MAPK2_HUMAN)search Homo sapienssearch 100% 356 93%
B Mitogen-activated protein kinase 14 P47811 (2-360) (MK14_MOUSE)search Mus musculussearch 97% 366 92%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P49137 (47 - 400) MAP kinase-activated protein kinase 2 Homo sapiens
P47811 (2 - 360) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P49137) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search, MAP kinase activated protein kinase 2search PF00069: Protein kinase domainsearch
B (P47811) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P49137) protein phosphorylationsearch protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch
B (P47811) protein phosphorylationsearch positive regulation of myotube differentiationsearch cellular response to DNA damage stimulussearch positive regulation of erythrocyte differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to lipopolysaccharidesearch skeletal muscle tissue developmentsearch positive regulation of myoblast fusionsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch response to muramyl dipeptidesearch cellular response to ionizing radiationsearch positive regulation of reactive oxygen species metabolic processsearch myoblast differentiation involved in skeletal muscle regenerationsearch intracellular signal transductionsearch positive regulation of myoblast differentiationsearch signal transduction in response to DNA damagesearch regulation of transcription, DNA-templatedsearch vascular endothelial growth factor receptor signaling pathwaysearch cell morphogenesissearch response to stresssearch angiogenesissearch negative regulation of canonical Wnt signaling pathwaysearch striated muscle cell differentiationsearch cellular response to vascular endothelial growth factor stimulussearch lipopolysaccharide-mediated signaling pathwaysearch peptidyl-serine phosphorylationsearch positive regulation of protein import into nucleussearch regulation of transcription from RNA polymerase II promotersearch apoptotic processsearch p38MAPK cascadesearch response to lipopolysaccharidesearch chondrocyte differentiationsearch cartilage condensationsearch glucose metabolic processsearch stress-induced premature senescencesearch fatty acid oxidationsearch osteoclast differentiationsearch DNA damage checkpointsearch transcription, DNA-templatedsearch phosphorylationsearch MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch NFAT protein bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch nucleotide bindingsearch cytosolsearch spindle polesearch extracellular vesicular exosomesearch nucleussearch cellsearch cytoplasmsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch MAP kinase activated protein kinase, C-terminal domainsearch
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch