Indomethacin-(R)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1
The structure was published by Harman, C.A., Turman, M.V., Kozak, K.R., Marnett, L.J., Smith, W.L., and Garavito, R.M., in 2007 in a paper entitled "Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.85 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Prostaglandin G/H synthase 1. This molecule has the UniProt identifier P05979 (PGH1_SHEEP). The sample contained 600 residues which is < 90% of the natural sequence. Out of 600 residues 539 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: