2oye Summary


Indomethacin-(R)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1

The structure was published by Harman, C.A., Turman, M.V., Kozak, K.R., Marnett, L.J., Smith, W.L., and Garavito, R.M., in 2007 in a paper entitled "Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.85 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Prostaglandin G/H synthase 1. This molecule has the UniProt identifier P05979 (PGH1_SHEEP)search. The sample contained 600 residues which is < 90% of the natural sequence. Out of 600 residues 539 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
P Prostaglandin G/H synthase 1 P05979 (1-600) (PGH1_SHEEP)search Ovis ariessearch 96% 600 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (1 - 600) Prostaglandin G/H synthase 1 Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
P (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO)
P (P05979) prostaglandin biosynthetic processsearch inflammatory responsesearch response to oxidative stresssearch regulation of blood pressuresearch cyclooxygenase pathwaysearch oxidation-reduction processsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch heme bindingsearch

Chain InterPro annotation
P Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search