2oxy Summary


Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32

The structure was published by Battistutta, R., Mazzorana, M., Cendron, L., et al., Zanotti, G., Moro, S., and Pinna, L.A., in 2007 in a paper entitled "The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.812 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Casein kinase II subunit alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Casein kinase II subunit alpha P28523 (1-332) (CSK2A_MAIZE)search Zea mayssearch 98% 332 98%
B Casein kinase II subunit alpha P28523 (1-332) (CSK2A_MAIZE)search Zea mayssearch 98% 332 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28523 (1 - 332) Casein kinase II subunit alpha Zea mays

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P28523) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P28523) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch nucleotide bindingsearch protein kinase activitysearch protein phosphorylationsearch phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch