2ow3 Summary

pdbe.org/2ow3
spacer

Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor

The structure was published by Zhang, H.C., Bonaga, L.V., Ye, H., Derian, C.K., Damiano, B.P., and Maryanoff, B.E., in 2007 in a paper entitled "Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (35-386) (GSK3B_HUMAN)search Homo sapienssearch 91% 352 100%
B Glycogen synthase kinase-3 beta P49841 (35-386) (GSK3B_HUMAN)search Homo sapienssearch 91% 352 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (35 - 386) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P49841) protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch