2ovr Summary


Structure of the Skp1-Fbw7-CyclinEdegN complex

The structure was published by Hao, B., Oehlmann, S., Sowa, M.E., Harper, J.W., and Pavletich, N.P., in 2007 in a paper entitled "Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely S-phase kinase-associated protein 1A, F-box/WD repeat protein 7, and cyclinE N-terminal degron.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S-phase kinase-associated protein 1A P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (82-149) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
149 91%
B F-box/WD repeat protein 7 Q969H0 (263-707) (FBXW7_HUMAN)search Homo sapienssearch < 90% 445 99%
C cyclinE N-terminal degron Not available
Synthetic Not available 8 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P63208 (1 - 69) S-phase kinase-associated protein 1A Homo sapiens
Q969H0 (263 - 707) F-box/WD repeat protein 7 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P63208) BTB/POZ domainsearch, Skp1 dimerisation domain-likesearch PF03931: Skp1 family, tetramerisation domainsearch, PF01466: Skp1 family, dimerisation domainsearch
B F-box domainsearch, WD40-repeatsearch YVTN repeat-like/Quinoprotein amine dehydrogenasesearch WD domain, G-beta repeatsearch, F-box-likesearch

Chain ID Biological process (GO)
A (P63208) ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A S-phase kinase-associated protein 1-likesearch BTB/POZ foldsearch SKP1 component, dimerisationsearch SKP1 component, POZ domainsearch S-phase kinase-associated protein 1search
B WD40 repeatsearch F-box domainsearch WD40/YVTN repeat-like-containing domainsearch WD40-repeat-containing domainsearch WD40 repeat, conserved sitesearch G-protein beta WD-40 repeatsearch