PDBe Entry: 2ovp

Structure of the Skp1-Fbw7 complex

Summary

Header

TRANSCRIPTION/CELL CYCLE

Method

X-RAY DIFFRACTION

Experiment

Resolution: 2.9 Å, R-factor: 23.5%, Free R-factor: 26.8%, Spacegroup: I 41 2 2

Released

24/04/2007, deposition: 14/02/2007, last revision: 24/02/2009

Authors

Hao, B.

; Oehlmann, S.

; Sowa, M.E.

; Harper, J.W.

; Pavletich, N.P.

Primary citation

Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases
MOL.CELL

vol:26, pag:131-143 (2007) [PubMed ID 17434132 ]

Keywords

F-box; WD40 domains

, TRANSCRIPTION/CELL CYCLE COMPLEX

Organism

Homo sapiens(human) 9606

(A B)

UniProt

S-phase kinase-associated protein 1 (Cyclin A/CDK2-associated protein p19) (p19skp1) (p19A) (RNA polymerase II elongation factor-like protein) (Organ of Corti protein 2) (OCP-2) (OCP-II) (Transcription elongation factor B) (SIII) P63208

(A)
F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10) Q969H0

(B)

Solvent

A, B

Related entries

2ovq, 2ovr

Polymers

Id	Name	Type	UniProt	Residues	Observed
A	S-phase kinase-associated protein 1A	Protein	P63208 (SKP1_HUMAN)	149	89%
B	F-box/WD repeat protein 7	Protein	Q969H0 (FBXW7_HUMAN)	445	99%