2ovm Summary


Progesterone Receptor with Bound Asoprisnil and a Peptide from the Co-Repressor NCoR

The structure was published by Madauss, K.P., Grygielko, E.T., Deng, S.J., et al., Laping, N.J., Williams, S.P., and Bray, J.D., in 2007 in a paper entitled "A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Progesterone receptor and NCoR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Progesterone receptor P06401 (678-933) (PRGR_HUMAN)search Homo sapienssearch < 90% 256 94%
B NCoR Not available
Synthetic Not available 25 44%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06401 (678 - 933) Progesterone receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P06401) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch