2ou7 Summary

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Structure of the Catalytic Domain of Human Polo-like Kinase 1

The structure was published by Kothe, M., Kohls, D., Low, S., et al., Wynn, T.A., Kuhn, C., and Ding, Y.H., in 2007 in a paper entitled "Structure of the catalytic domain of human polo-like kinase 1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase PLK1. This molecule has the UniProt identifier P53350 (PLK1_HUMAN)search. The sample contained 335 residues which is < 90% of the natural sequence. Out of 335 residues 292 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase PLK1 P53350 (13-345) (PLK1_HUMAN)search Homo sapienssearch < 90% 335 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53350 (13 - 345) Serine/threonine-protein kinase PLK1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P53350) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch