› 2ot5

X-ray diffraction
1.8Å resolution

Crystal structure of the HIV gp41 core with the enfuvirtide resistance mutation N43D

Released:
DOI: 10.2210/pdb2ot5/pdb
PDB entry 2ot5 coloured by chain, front view.
PDB entry 2ot5 coloured by chain, side view.
PDB entry 2ot5 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure.
Bai X, Wilson KL, Seedorff JE, Ahrens D, Green J, Davison DK, Jin L, Stanfield-Oakley SA, Mosier SM, Melby TE, Cammack N, Wang Z, Greenberg ML, Dwyer JJ
Biochemistry 47 6662-70 (2008)
PMID: 18507398

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.88 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53I19 (Residues: 17-126; Coverage: 48%)
Gene name: gp41
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: R3
Unit cell:
a: 51.025Å b: 51.025Å c: 59.668Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.234 0.258
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Molecular basis of human immunodeficiency virus drug resistance: an update.
Menéndez-Arias L. (2010)
3 more

3 mentions without citation

HIV-1 envelope glycoprotein structure.
Merk et al. (2013)
2 more