2osm Summary


Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study

The structure was published by Barrese, A.A., Genis, C., Fisher, S.Z., et al., Agbandje-McKenna, M., McKenna, R., and Tripp, B.C., in 2008 in a paper entitled "Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch bicarbonate transportsearch secretionsearch morphogenesis of an epitheliumsearch response to pHsearch cellular response to fluid shear stresssearch positive regulation of bone resorptionsearch kidney developmentsearch regulation of chloride transportsearch positive regulation of cellular pH reductionsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch regulation of anion transportsearch response to zinc ionsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch one-carbon metabolic processsearch membranesearch microvillussearch cytosolsearch basolateral plasma membranesearch cytoplasmsearch extracellular vesicular exosomesearch apical part of cellsearch plasma membranesearch axonsearch myelin sheathsearch extracellular spacesearch carbonate dehydratase activitysearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch