2os8 Summary


Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor

The structure was published by Yang, Y., Gourinath, S., Kovacs, M., et al., Szent-Gyorgyi, A.G., Brown, J.H., and Cohen, C., in 2007 in a paper entitled "Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.27 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Myosin heavy chain, Myosin regulatory light chain, and Myosin essential light chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myosin heavy chain Q26080 (1-840) (Q26080_PLAMG)search Placopecten magellanicussearch < 90% 840 95%
B Myosin regulatory light chain Q26068 (1-157) (Q26068_PLAMG)search Placopecten magellanicussearch 100% 157 85%
C Myosin essential light chain Q26066 (1-157) (Q26066_PLAMG)search Placopecten magellanicussearch 99% 157 98%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q26080 (1 - 840) Myosin heavy chain Placopecten magellanicus
Q26068 (1 - 157) Myosin regulatory light chain Placopecten magellanicus
Q26066 (1 - 157) Myosin essential light chain Placopecten magellanicus

Chain Structural classification (CATH) Sequence family (Pfam)
A Myosin head (motor domain)search, Myosin N-terminal SH3-like domainsearch
B (Q26068) EF-handsearch PF13499: EF-hand domain pairsearch
C (Q26066) EF-handsearch PF13499: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (Q26080) ATP bindingsearch motor activitysearch myosin complexsearch
B (Q26068) calcium ion bindingsearch metal ion bindingsearch
C (Q26066) calcium ion bindingsearch metal ion bindingsearch

Chain InterPro annotation
A IQ motif, EF-hand binding sitesearch Myosin head, motor domainsearch Myosin, N-terminal, SH3-likesearch Myosin-like IQ motif-containing domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C EF-hand domainsearch EF-hand domain pairsearch