2or3 Summary

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Pre-oxidation Complex of Human DJ-1

The structure was published by Witt, A.C., Lakshminarasimhan, M., Remington, B.C., Hasim, S., Pozharski, E., and Wilson, M.A., in 2008 in a paper entitled "Cysteine pKa depression by a protonated glutamic acid in human DJ-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.2 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein DJ-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 98%
B Protein DJ-1 Q99497 (1-189) (PARK7_HUMAN)search Homo sapienssearch 99% 189 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99497 (1 - 189) Protein DJ-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q99497) DJ-1/PfpIsearch Rossmann foldsearch PF01965: DJ-1/PfpI familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q99497) response to stresssearch cellular response to hydrogen peroxidesearch positive regulation of oxidative phosphorylation uncoupler activitysearch mitochondrion organizationsearch hydrogen peroxide metabolic processsearch cellular response to oxidative stresssearch negative regulation of hydrogen peroxide-induced cell deathsearch positive regulation of androgen receptor activitysearch glycolate biosynthetic processsearch negative regulation of apoptotic processsearch negative regulation of ubiquitin-protein transferase activitysearch positive regulation of transcription from RNA polymerase II promotersearch response to hydrogen peroxidesearch negative regulation of oxidative stress-induced cell deathsearch negative regulation of protein bindingsearch cell deathsearch negative regulation of protein export from nucleussearch regulation of neuron apoptotic processsearch lactate biosynthetic processsearch dopamine uptake involved in synaptic transmissionsearch regulation of inflammatory responsesearch positive regulation of dopamine biosynthetic processsearch cellular response to reactive oxygen speciessearch negative regulation of hydrogen peroxide-induced neuron deathsearch negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaysearch methylglyoxal catabolic process to D-lactatesearch glyoxal catabolic processsearch positive regulation of interleukin-8 productionsearch negative regulation of protein acetylationsearch adult locomotory behaviorsearch negative regulation of neuron deathsearch negative regulation of ubiquitin-specific protease activitysearch negative regulation of cell deathsearch negative regulation of protein sumoylationsearch synaptic transmission, dopaminergicsearch negative regulation of protein kinase activitysearch negative regulation of neuron apoptotic processsearch cellular response to glyoxalsearch negative regulation of protein ubiquitinationsearch negative regulation of protein phosphorylationsearch membrane depolarizationsearch negative regulation of extrinsic apoptotic signaling pathwaysearch protein stabilizationsearch autophagysearch negative regulation of gene expressionsearch positive regulation of pyrroline-5-carboxylate reductase activitysearch inflammatory responsesearch positive regulation of protein homodimerization activitysearch regulation of mitochondrial membrane potentialsearch positive regulation of L-dopa decarboxylase activitysearch negative regulation of death-inducing signaling complex assemblysearch negative regulation of TRAIL-activated apoptotic signaling pathwaysearch positive regulation of L-dopa biosynthetic processsearch positive regulation of protein localization to nucleussearch positive regulation of tyrosine 3-monooxygenase activitysearch membrane hyperpolarizationsearch positive regulation of superoxide dismutase activitysearch regulation of androgen receptor signaling pathwaysearch oxidation-reduction processsearch regulation of TRAIL receptor biosynthetic processsearch positive regulation of mitochondrial electron transport, NADH to ubiquinonesearch single fertilizationsearch negative regulation of protein K48-linked deubiquitinationsearch proteolysissearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaysearch protein bindingsearch ubiquitin-specific protease bindingsearch enzyme bindingsearch identical protein bindingsearch single-stranded DNA bindingsearch repressing transcription factor bindingsearch tyrosine 3-monooxygenase activator activitysearch glyoxalase III activitysearch peptidase activitysearch small protein activating enzyme bindingsearch cytokine bindingsearch transcription factor bindingsearch RNA bindingsearch superoxide dismutase copper chaperone activitysearch mRNA bindingsearch small protein conjugating enzyme bindingsearch androgen receptor bindingsearch cupric ion bindingsearch peroxiredoxin activitysearch scaffold protein bindingsearch double-stranded DNA bindingsearch transcription coactivator activitysearch protein homodimerization activitysearch oxidoreductase activity, acting on peroxide as acceptorsearch L-dopa decarboxylase activator activitysearch peroxidase activitysearch hydrolase activitysearch receptor bindingsearch cuprous ion bindingsearch glyoxalase (glycolic acid-forming) activitysearch core promoter bindingsearch mitochondrial respiratory chain complex Isearch cytoplasmsearch mitochondrionsearch chromatinsearch plasma membranesearch cytosolsearch nucleussearch extracellular vesicular exosomesearch PML bodysearch membranesearch membrane raftsearch

Chain InterPro annotation
A, B ThiJ/PfpIsearch DJ-1search Class I glutamine amidotransferase-likesearch