2oq1 Summary


Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide

The structure was published by Hatada, M.H., Lu, X., Laird, E.R., et al., Phillips, T.B., Ram, M.K., and Theriault, K., in 1995 in a paper entitled "Molecular basis for the interaction of ZAP-70 with the T-cell receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Tyrosine-protein kinase ZAP-70 and T-cell surface glycoprotein CD3 zeta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase ZAP-70 P43403 (3-256) (ZAP70_HUMAN)search Homo sapienssearch 98% 254 100%
B T-cell surface glycoprotein CD3 zeta chain P20963 (69-87) (CD3Z_HUMAN)search Homo sapienssearch < 90% 19 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P43403 (3 - 256) Tyrosine-protein kinase ZAP-70 Homo sapiens
P20963 (69 - 87) T-cell surface glycoprotein CD3 zeta chain

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P43403) SH2 domainsearch SHC Adaptor Proteinsearch, Syk Kinase; Chain A, domain 2search PF00017: SH2 domainsearch
B Immunoreceptor tyrosine-based activation motifsearch

Chain ID Molecular function (GO)
A (P43403) non-membrane spanning protein tyrosine kinase activitysearch

Chain InterPro annotation
A SH2 domainsearch Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domainsearch
B Phosphorylated immunoreceptor signalling ITAMsearch