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PDBe Entry: 2ony 
Structure of hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy
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Transferase
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X-RAY DIFFRACTION
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Resolution: 2.6 Å, R-factor: 22.3%, Free R-factor: 25.8%, Spacegroup: P 43 21 2
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09/10/2007, deposition: 24/01/2007, last revision: 24/02/2009
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Drinkwater, N.; Martin, J.L.
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Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase
J.MED.CHEM. vol:50, pag:4845-4853 (2007) [PubMed ID 17845018 ]
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methyltransferase
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2.1.1.28 ExPASy BRENDA (A B)
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Homo sapiens(human) 9606(A B)
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Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase) P11086 (A B)
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A, B
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2g8n, 1hnn, 2onz
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| A, B |
Phenylethanolamine N-methyltransferase |
Protein |
P11086 (PNMT_HUMAN)
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289 |
92% |
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| B |
PHOSPHATE ION |
PO4
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| A, B |
S-ADENOSYL-L-HOMOCYSTEINE |
SAH
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| A |
N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE |
TMJ
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