2onl Summary

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Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer

The structure was published by ter Haar, E., Prabakhar, P., Liu, X., and Lepre, C., in 2007 in a paper entitled "Crystal structure of the P38alpha-MAPKAP kinase 2 heterodimer." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Mitogen-activated protein kinase 14 and MAP kinase-activated protein kinase 2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 92%
B Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 92%
C MAP kinase-activated protein kinase 2 P49137 (1-400) (MAPK2_HUMAN)search Homo sapienssearch 100% 406 78%
D MAP kinase-activated protein kinase 2 P49137 (1-400) (MAPK2_HUMAN)search Homo sapienssearch 100% 406 78%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens
P49137 (1 - 400) MAP kinase-activated protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
C, D (P49137) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search, MAP kinase activated protein kinase 2search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q16539) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase activitysearch protein bindingsearch MAP kinase kinase activitysearch NFAT protein bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch nucleotide bindingsearch kinase activitysearch protein phosphorylationsearch peptidyl-serine phosphorylationsearch regulation of sequence-specific DNA binding transcription factor activitysearch cartilage condensationsearch toll-like receptor 5 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch response to stresssearch phosphorylationsearch p38MAPK cascadesearch cellular response to vascular endothelial growth factor stimulussearch RNA metabolic processsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch signal transductionsearch cellular response to DNA damage stimulussearch Ras protein signal transductionsearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of myoblast differentiationsearch mRNA metabolic processsearch stress-induced premature senescencesearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch cellular component movementsearch chemotaxissearch negative regulation of canonical Wnt signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch striated muscle cell differentiationsearch response to muramyl dipeptidesearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch platelet activationsearch toll-like receptor 4 signaling pathwaysearch positive regulation of muscle cell differentiationsearch DNA damage checkpointsearch lipopolysaccharide-mediated signaling pathwaysearch fatty acid oxidationsearch regulation of transcription, DNA-templatedsearch toll-like receptor 3 signaling pathwaysearch osteoclast differentiationsearch innate immune responsesearch response to lipopolysaccharidesearch MyD88-independent toll-like receptor signaling pathwaysearch angiogenesissearch chondrocyte differentiationsearch muscle cell differentiationsearch cell surface receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch vascular endothelial growth factor receptor signaling pathwaysearch signal transduction in response to DNA damagesearch positive regulation of erythrocyte differentiationsearch glucose metabolic processsearch cellular response to lipopolysaccharidesearch positive regulation of myoblast fusionsearch transcription, DNA-templatedsearch activation of MAPK activitysearch MyD88-dependent toll-like receptor signaling pathwaysearch blood coagulationsearch gene expressionsearch stress-activated MAPK cascadesearch positive regulation of myotube differentiationsearch skeletal muscle tissue developmentsearch cell morphogenesissearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cellular response to ionizing radiationsearch 3'-UTR-mediated mRNA stabilizationsearch regulation of transcription from RNA polymerase II promotersearch apoptotic processsearch MAPK cascadesearch positive regulation of protein import into nucleussearch intracellular signal transductionsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cytosolsearch nucleussearch nucleoplasmsearch cytoplasmsearch spindle polesearch cellsearch mitochondrionsearch extracellular vesicular exosomesearch
C, D (P49137) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch signal transducer activitysearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch transferase activitysearch protein phosphorylationsearch mRNA stabilizationsearch MyD88-dependent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch activation of MAPK activitysearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch regulation of interleukin-6 productionsearch G2 DNA damage checkpointsearch MAPK cascadesearch gene expressionsearch toll-like receptor 10 signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch macropinocytosissearch cellular response to DNA damage stimulussearch toll-like receptor 4 signaling pathwaysearch inflammatory responsesearch response to stresssearch toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch arachidonic acid metabolic processsearch toll-like receptor 9 signaling pathwaysearch response to lipopolysaccharidesearch stress-activated MAPK cascadesearch regulation of tumor necrosis factor productionsearch leukotriene metabolic processsearch inner ear developmentsearch neurotrophin TRK receptor signaling pathwaysearch response to cytokinesearch small molecule metabolic processsearch innate immune responsesearch RNA metabolic processsearch cellular response to vascular endothelial growth factor stimulussearch mRNA metabolic processsearch phosphorylationsearch 3'-UTR-mediated mRNA stabilizationsearch peptidyl-serine phosphorylationsearch cytoplasmsearch nucleussearch nucleolussearch cytosolsearch nucleoplasmsearch centrosomesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
C, D Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch MAP kinase activated protein kinase, C-terminal domainsearch