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Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer

X-ray diffraction
4Å resolution
PDB entry 2onl coloured by chain, front view.
PDB entry 2onl coloured by chain, side view.
PDB entry 2onl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MAP kinase-activated protein kinase 2 and Mitogen-activated protein kinase 14
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Multimeric state: hetero dimer
Accessible surface area: 31959.44 Å2
Buried surface area: 3523.69 Å2
Dissociation area: 1,761.85 Å2
Dissociation energy (ΔGdiss): 11.19 kcal/mol
Dissociation entropy (TΔSdiss): 13.89 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155866
Assembly 2
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Assembly Name: MAP kinase-activated protein kinase 2 and Mitogen-activated protein kinase 14
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Multimeric state: hetero dimer
Accessible surface area: 31865.45 Å2
Buried surface area: 3207.84 Å2
Dissociation area: 1,603.92 Å2
Dissociation energy (ΔGdiss): 2.93 kcal/mol
Dissociation entropy (TΔSdiss): 13.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155866

Macromolecules

Mitogen-activated protein kinase 14
Chains: A, B
Length: 366 amino acids
Theoretical weight: 42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Mitogen-activated protein kinase 14 in PDB entry 2onl, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 2onl, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 2onl, assembly 1, top view.
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MAP kinase-activated protein kinase 2
Chains: C, D
Length: 406 amino acids
Theoretical weight: 46.29 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49137 (Residues: 1-400; Coverage: 100%)
Gene name: MAPKAPK2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
MAP kinase-activated protein kinase 2 in PDB entry 2onl, assembly 1, front view.
MAP kinase-activated protein kinase 2 in PDB entry 2onl, assembly 1, side view.
MAP kinase-activated protein kinase 2 in PDB entry 2onl, assembly 1, top view.
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