2olz Summary

pdbe.org/2olz
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Structure of human insulin in presence of thiocyanate at pH 7.0

The structure was published by Norrman, M. and Schluckebier, G., in 2007 in a paper entitled "Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Insulin A and Insulin B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin A P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
C Insulin A P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
E Insulin A P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
G Insulin A P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
I Insulin A P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
K Insulin A P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
B Insulin B P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 96%
D Insulin B P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 96%
F Insulin B P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 96%
H Insulin B P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 96%
J Insulin B P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 96%
L Insulin B P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (90 - 110) Insulin A Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C, E, G, I, K (P01308) PF00049: Insulin/IGF/Relaxin familysearch
B, D, F, H, J, L (P01308) Isolated insulin B-chainsearch PF00049: Insulin/IGF/Relaxin familysearch

Chain ID Molecular function (GO) Cellular component (GO)
A, C, E, G, I, K (P01308) hormone activitysearch extracellular regionsearch
B, D, F, H, J, L (P01308) hormone activitysearch extracellular regionsearch

Chain InterPro annotation
A, C, E, G, I, K Insulin-likesearch Insulin, conserved sitesearch
B, D, F, H, J, L Insulinsearch Insulin-likesearch