2okk Summary

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The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65)

The structure was published by Fenalti, G., Law, R.H., Buckle, A.M., et al., Mackay, I.R., Rowley, M.J., and Whisstock, J.C., in 2007 in a paper entitled "GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glutamate decarboxylase 2. This molecule has the UniProt identifier Q05329 (DCE2_HUMAN)search. The sample contained 497 residues which is < 90% of the natural sequence. Out of 497 residues 473 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutamate decarboxylase 2 Q05329 (88-584) (DCE2_HUMAN)search Homo sapienssearch < 90% 497 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05329 (88 - 584) Glutamate decarboxylase 2 Homo sapiens

Chain Sequence family (Pfam)
A Pyridoxal-dependent decarboxylase conserved domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q05329) carboxylic acid metabolic processsearch carboxy-lyase activitysearch pyridoxal phosphate bindingsearch catalytic activitysearch

Chain InterPro annotation
A Pyridoxal phosphate-dependent decarboxylasesearch Pyridoxal phosphate-dependent transferase, major region, subdomain 1search Pyridoxal phosphate-dependent transferase, major region, subdomain 2search Pyridoxal phosphate-dependent transferasesearch Pyridoxal-phosphate binding sitesearch