2okj Summary


The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67)

The structure was published by Fenalti, G., Law, R.H.P., Buckle, A.M., et al., Mackay, I.R., Rowley, M.J., and Whisstock, J.C., in 2007 in a paper entitled "GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glutamate decarboxylase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutamate decarboxylase 1 Q99259 (93-594) (DCE1_HUMAN)search Homo sapienssearch < 90% 504 100%
B Glutamate decarboxylase 1 Q99259 (93-594) (DCE1_HUMAN)search Homo sapienssearch < 90% 504 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q99259 (93 - 594) Glutamate decarboxylase 1 Homo sapiens

Chain Sequence family (Pfam)
A, B Pyridoxal-dependent decarboxylase conserved domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q99259) pyridoxal phosphate bindingsearch carboxy-lyase activitysearch catalytic activitysearch carboxylic acid metabolic processsearch

Chain InterPro annotation
A, B Pyridoxal phosphate-dependent decarboxylasesearch Pyridoxal phosphate-dependent transferase, major region, subdomain 1search Pyridoxal phosphate-dependent transferase, major region, subdomain 2search Pyridoxal phosphate-dependent transferasesearch Pyridoxal-phosphate binding sitesearch