2ojj Summary


Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide

The structure was published by Aronov, A.M., Baker, C., Bemis, G.W., et al., Straub, J., Tang, Q., and Xie, X., in 2007 in a paper entitled "Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 1. This molecule has the UniProt identifier P28482 (MK01_HUMAN)search. The sample contained 380 residues which is 100% of the natural sequence. Out of 380 residues 344 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 1 P28482 (2-360) (MK01_HUMAN)search Homo sapienssearch 97% 380 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28482 (2 - 360) Mitogen-activated protein kinase 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P28482) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P28482) Golgi apparatussearch mitochondrionsearch cytoplasmsearch nucleussearch late endosomesearch cytosolsearch perikaryonsearch microtubule cytoskeletonsearch spindlesearch focal adhesionsearch dendrite cytoplasmsearch nucleoplasmsearch cytoskeletonsearch mitotic spindlesearch microtubule organizing centersearch nucleolussearch extracellular vesicular exosomesearch pseudopodiumsearch protein complexsearch caveolasearch early endosomesearch protein bindingsearch kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch MAP kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transcription factor bindingsearch RNA polymerase II carboxy-terminal domain kinase activitysearch phosphotyrosine bindingsearch phosphatase bindingsearch DNA bindingsearch nucleotide bindingsearch mitogen-activated protein kinase kinase kinase bindingsearch response to lipopolysaccharidesearch transcription, DNA-templatedsearch insulin receptor signaling pathwaysearch response to epidermal growth factorsearch MyD88-dependent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch blood coagulationsearch positive regulation of cell migrationsearch B cell receptor signaling pathwaysearch epidermal growth factor receptor signaling pathwaysearch response to toxic substancesearch cytosine metabolic processsearch intracellular signal transductionsearch innate immune responsesearch ERBB signaling pathwaysearch JAK-STAT cascade involved in growth hormone signaling pathwaysearch positive regulation of cell proliferationsearch ERK1 and ERK2 cascadesearch sensory perception of painsearch labyrinthine layer blood vessel developmentsearch protein phosphorylationsearch toll-like receptor 9 signaling pathwaysearch positive regulation of transcription, DNA-templatedsearch neurotrophin TRK receptor signaling pathwaysearch MAPK cascadesearch caveolin-mediated endocytosissearch toll-like receptor 3 signaling pathwaysearch cellular response to granulocyte macrophage colony-stimulating factor stimulussearch signal transductionsearch regulation of cytoskeleton organizationsearch organ morphogenesissearch MAPK import into nucleussearch lipopolysaccharide-mediated signaling pathwaysearch synaptic transmissionsearch viral processsearch positive regulation of peptidyl-threonine phosphorylationsearch regulation of Golgi inheritancesearch apoptotic processsearch positive regulation of translationsearch fibroblast growth factor receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch response to stresssearch peptidyl-threonine phosphorylationsearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch activation of MAPK activitysearch toll-like receptor 5 signaling pathwaysearch regulation of transcription, DNA-templatedsearch small GTPase mediated signal transductionsearch Fc-epsilon receptor signaling pathwaysearch T cell receptor signaling pathwaysearch regulation of protein stabilitysearch TRIF-dependent toll-like receptor signaling pathwaysearch response to exogenous dsRNAsearch cellular response to DNA damage stimulussearch regulation of stress-activated MAPK cascadesearch activation of MAPKK activitysearch toll-like receptor 4 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch phosphorylationsearch response to estrogensearch cell cyclesearch axon guidancesearch chemotaxissearch Fc-gamma receptor signaling pathway involved in phagocytosissearch platelet activationsearch mammary gland epithelial cell proliferationsearch regulation of early endosome to late endosome transportsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch negative regulation of cell differentiationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch