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Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide

The structure was published by Aronov, A.M., Baker, C., Bemis, G.W., et al., Straub, J., Tang, Q., and Xie, X., in 2007 in a paper entitled "Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 1. This molecule has the UniProt identifier P28482 (MK01_HUMAN)search. The sample contained 380 residues which is 100% of the natural sequence. Out of 380 residues 343 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 1 P28482 (2-360) (MK01_HUMAN)search Homo sapienssearch 97% 380 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P28482 (2 - 360) Mitogen-activated protein kinase 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P28482) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P28482) ATP bindingsearch nucleotide bindingsearch protein bindingsearch MAP kinase activitysearch protein serine/threonine kinase activitysearch RNA polymerase II carboxy-terminal domain kinase activitysearch phosphotyrosine bindingsearch protein kinase activitysearch transcription factor bindingsearch kinase activitysearch protein kinase bindingsearch mitogen-activated protein kinase kinase kinase bindingsearch transferase activity, transferring phosphorus-containing groupssearch phosphatase bindingsearch transferase activitysearch DNA bindingsearch toll-like receptor 9 signaling pathwaysearch cellular response to DNA damage stimulussearch transcription, DNA-templatedsearch signal transductionsearch lipopolysaccharide-mediated signaling pathwaysearch sensory perception of painsearch positive regulation of cell migrationsearch Fc-epsilon receptor signaling pathwaysearch organ morphogenesissearch apoptotic processsearch ERK1 and ERK2 cascadesearch MyD88-dependent toll-like receptor signaling pathwaysearch platelet activationsearch protein phosphorylationsearch positive regulation of translationsearch toll-like receptor 10 signaling pathwaysearch negative regulation of cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch synaptic transmissionsearch toll-like receptor 5 signaling pathwaysearch small GTPase mediated signal transductionsearch positive regulation of transcription, DNA-templatedsearch MAPK cascadesearch axon guidancesearch response to estrogensearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch response to stresssearch mammary gland epithelial cell proliferationsearch toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch blood coagulationsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of cell proliferationsearch response to toxic substancesearch peptidyl-threonine phosphorylationsearch labyrinthine layer blood vessel developmentsearch response to epidermal growth factorsearch toll-like receptor 3 signaling pathwaysearch Fc-gamma receptor signaling pathway involved in phagocytosissearch response to lipopolysaccharidesearch cellular response to granulocyte macrophage colony-stimulating factor stimulussearch chemotaxissearch TRIF-dependent toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch activation of MAPK activitysearch innate immune responsesearch MAPK import into nucleussearch response to exogenous dsRNAsearch JAK-STAT cascade involved in growth hormone signaling pathwaysearch caveolin-mediated endocytosissearch regulation of early endosome to late endosome transportsearch T cell receptor signaling pathwaysearch intracellular signal transductionsearch regulation of transcription, DNA-templatedsearch epidermal growth factor receptor signaling pathwaysearch Ras protein signal transductionsearch toll-like receptor 4 signaling pathwaysearch ERBB signaling pathwaysearch stress-activated MAPK cascadesearch positive regulation of peptidyl-threonine phosphorylationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to organic substancesearch regulation of protein stabilitysearch viral processsearch regulation of Golgi inheritancesearch phosphorylationsearch activation of MAPKK activitysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch regulation of cytoskeleton organizationsearch insulin receptor signaling pathwaysearch cytosine metabolic processsearch B cell receptor signaling pathwaysearch regulation of stress-activated MAPK cascadesearch cell cyclesearch cytosolsearch nucleussearch nucleoplasmsearch perikaryonsearch focal adhesionsearch caveolasearch early endosomesearch mitochondrionsearch protein complexsearch pseudopodiumsearch microtubule organizing centersearch late endosomesearch dendrite cytoplasmsearch extracellular vesicular exosomesearch cytoplasmsearch Golgi apparatussearch mitotic spindlesearch spindlesearch cytoskeletonsearch microtubule cytoskeletonsearch axonsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch