2ojf Summary


Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors

The structure was published by Zhu, G.D., Gong, J., Gandhi, V.B., et al., Li, Q., Rosenberg, S.H., and Giranda, V.L., in 2007 in a paper entitled "Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-dependent protein kinase, alpha-catalytic subunit and Inhibitory peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E cAMP-dependent protein kinase, alpha-catalytic subunit P00517 (1-351) (KAPCA_BOVIN)search Bos taurussearch 96% 351 95%
I Inhibitory peptide Not available
Not available Not available 20 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00517 (1 - 351) cAMP-dependent protein kinase, alpha-catalytic subunit Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E (P00517) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
E (P00517) protein kinase activitysearch transferase activitysearch protein kinase bindingsearch ubiquitin protein ligase bindingsearch kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch cAMP-dependent protein kinase activitysearch protein bindingsearch protein kinase A regulatory subunit bindingsearch ATP bindingsearch positive regulation of protein export from nucleussearch protein autophosphorylationsearch regulation of osteoblast differentiationsearch regulation of proteasomal protein catabolic processsearch peptidyl-serine phosphorylationsearch sperm capacitationsearch mesoderm formationsearch regulation of synaptic transmissionsearch phosphorylationsearch cellular response to parathyroid hormone stimulussearch cellular response to glucose stimulussearch protein phosphorylationsearch regulation of tight junction assemblysearch positive regulation of cell cycle arrestsearch plasma membranesearch cytoplasmsearch mitochondrionsearch nucleussearch membranesearch neuromuscular junctionsearch sperm midpiecesearch AMP-activated protein kinase complexsearch centrosomesearch

Chain InterPro annotation
E Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch