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Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors

X-ray diffraction
2.1Å resolution
PDB entry 2ojf coloured by chain, front view.
PDB entry 2ojf coloured by chain, side view.
PDB entry 2ojf coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 15507.27 Å2
Buried surface area: 2803.58 Å2
Dissociation area: 983.34 Å2
Dissociation energy (ΔGdiss): 0.96 kcal/mol
Dissociation entropy (TΔSdiss): 9.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132595

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: E
Length: 351 amino acids
Theoretical weight: 40.68 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00517 (Residues: 1-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 2ojf, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 2ojf, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 2ojf, assembly 1, top view.
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Inhibitory peptide
Chain: I
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Bos taurus
Expression system: Not provided
InterPro: cAMP-dependent protein kinase inhibitor
Inhibitory peptide in PDB entry 2ojf, assembly 1, front view.
Inhibitory peptide in PDB entry 2ojf, assembly 1, side view.
Inhibitory peptide in PDB entry 2ojf, assembly 1, top view.
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