2oje Summary

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Mycoplasma arthritidis-derived mitogen complexed with class II MHC molecule HLA-DR1/HA complex in the presence of EDTA

The structure was published by Li, H., Zhao, Y., Guo, Y., Li, Z., Eisele, L., and Mourad, W., in 2007 in a paper entitled "Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This entry contains 19 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DR alpha chain precursor P01903 (27-206) (DRA_HUMAN)search Homo sapienssearch < 90% 180 100%
E HLA class II histocompatibility antigen, DR alpha chain precursor P01903 (27-206) (DRA_HUMAN)search Homo sapienssearch < 90% 180 100%
B HLA class II histocompatibility antigen, DRB1-1 beta chain precursor P04229 (30-219) (2B11_HUMAN)search Homo sapienssearch < 90% 190 100%
F HLA class II histocompatibility antigen, DRB1-1 beta chain precursor P04229 (30-219) (2B11_HUMAN)search Homo sapienssearch < 90% 190 100%
C haemagglutinin peptide 306-318 Q91LS8 (260-272) (Q91LS8_9INFA)search Influenza A virus (A/Taiwan/0095/1996(H3N2))search < 90% 13 100%
G haemagglutinin peptide 306-318 Q91LS8 (260-272) (Q91LS8_9INFA)search Influenza A virus (A/Taiwan/0095/1996(H3N2))search < 90% 13 100%
D Superantigen Q48898 (25-238) (Q48898_MYCAT)search Mycoplasma arthritidissearch 100% 214 100%
H Superantigen Q48898 (25-238) (Q48898_MYCAT)search Mycoplasma arthritidissearch 100% 214 100%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (27 - 206) HLA class II histocompatibility antigen, DR alpha chain precursor Homo sapiens
P04229 (30 - 219) HLA class II histocompatibility antigen, DRB1-1 beta chain precursor Homo sapiens
Q91LS8 (260 - 272) haemagglutinin peptide 306-318
Q48898 (25 - 238) Superantigen Mycoplasma arthritidis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, E C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B, F C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C, G Haemagglutininsearch
D, H Superantigen MAMsearch Hla class ii histocompatibility antigen, dr alpha chain. Chain D, domain 1search, mam-mhc complex, Chain D, Domain 2search Mycoplasma arthritidis-derived mitogensearch

Chain ID Biological process (GO) Cellular component (GO)
A, E (P01903) antigen processing and presentationsearch immune responsesearch MHC class II protein complexsearch membranesearch
B, F (P04229) antigen processing and presentationsearch immune responsesearch membranesearch MHC class II protein complexsearch

Chain InterPro annotation
A, E MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B, F MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C, G
D, H Mycoplasma arthritidis-derived mitogen, C-terminalsearch Mycoplasma arthritidis-derived mitogen, N-terminalsearch Mycoplasma arthritidis-derived mitogensearch