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Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen.

Li H, Zhao Y, Guo Y, Li Z, Eisele L, Mourad W
J Biol Chem 282 5991-6000 (2007)
Cited: 20 times
EuropePMC logo PMID: 17166841

Abstract

Dimerization of class II major histocompatibility complex (MHC) plays an important role in the MHC biological function. Mycoplasma arthritidis-derived mitogen (MAM) is a superantigen that can activate large fractions of T cells bearing specific T cell receptor Vbeta elements. Here we have used structural, sedimentation, and surface plasmon resonance detection approaches to investigate the molecular interactions between MAM and the class II MHC molecule HLA-DR1 in the context of a hemagglutinin peptide-(306-318) (HA). Our results revealed that zinc ion can efficiently induce the dimerization of the HLA-DR1/HA complex. Because the crystal structure of the MAM/HLA-DR1/hemagglutinin complex in the presence of EDTA is nearly identical to the structure of the complex crystallized in the presence of zinc ion, Zn(2+) is evidently not directly involved in the binding between MAM and HLA-DR1. Sedimentation and surface plasmon resonance studies further revealed that MAM binds the HLA-DR1/HA complex with high affinity in a 1:1 stoichiometry, in the absence of Zn(2+). However, in the presence of Zn(2+), a dimerized MAM/HLA-DR1/HA complex can arise through the Zn(2+)-induced DR1 dimer. In the presence of Zn(2+), cooperative binding of MAM to the DR1 dimer was also observed.

Reviews - 2oje mentioned but not cited (1)

  1. Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Painter CA, Stern LJ. Immunol Rev 250 144-157 (2012)

Articles - 2oje mentioned but not cited (8)

  1. TEPITOPEpan: extending TEPITOPE for peptide binding prediction covering over 700 HLA-DR molecules. Zhang L, Chen Y, Wong HS, Zhou S, Mamitsuka H, Zhu S. PLoS One 7 e30483 (2012)
  2. PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity. Oyarzún P, Ellis JJ, Bodén M, Kobe B. BMC Bioinformatics 14 52 (2013)
  3. Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen. Li H, Zhao Y, Guo Y, Li Z, Eisele L, Mourad W. J Biol Chem 282 5991-6000 (2007)
  4. An effective and effecient peptide binding prediction approach for a broad set of HLA-DR molecules based on ordered weighted averaging of binding pocket profiles. Shen WJ, Zhang S, Wong HS. Proteome Sci 11 S15 (2013)
  5. HASP server: a database and structural visualization platform for comparative models of influenza A hemagglutinin proteins. Ambroggio XI, Dommer J, Gopalan V, Dunham EJ, Taubenberger JK, Hurt DE. BMC Bioinformatics 14 197 (2013)
  6. A Novel Peptide Binding Prediction Approach for HLA-DR Molecule Based on Sequence and Structural Information. Li Z, Zhao Y, Pan G, Tang J, Guo F. Biomed Res Int 2016 3832176 (2016)
  7. Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange. Painter CA, Stern LJ. Curr Top Biochem Res 13 39-55 (2011)
  8. PANDORA v2.0: Benchmarking peptide-MHC II models and software improvements. Parizi FM, Marzella DF, Ramakrishnan G, 't Hoen PAC, Karimi-Jafari MH, Xue LC. Front Immunol 14 1285899 (2023)


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  3. Functional interaction of CD154 protein with α5β1 integrin is totally independent from its binding to αIIbβ3 integrin and CD40 molecules. El Fakhry Y, Alturaihi H, Yacoub D, Liu L, Guo W, Leveillé C, Jung D, Khzam LB, Merhi Y, Wilkins JA, Li H, Mourad W. J Biol Chem 287 18055-18066 (2012)
  4. A critical role for both CD40 and VLA5 in angiotensin II-mediated thrombosis and inflammation. Senchenkova EY, Russell J, Vital SA, Yildirim A, Orr AW, Granger DN, Gavins FNE. FASEB J 32 3448-3456 (2018)
  5. Pfit is a structurally novel Crohn's disease-associated superantigen. Liu L, Chen H, Brecher MB, Li Z, Wei B, Nandi B, Zhang J, Ling H, Winslow G, Braun J, Li H. PLoS Pathog 9 e1003837 (2013)
  6. Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer. Liu L, Li Z, Guo Y, VanVranken SJ, Mourad W, Li H. J Mol Biol 399 367-376 (2010)
  7. Mining Complex Genetic Patterns Conferring Multiple Sclerosis Risk. Briggs FBS, Sept C. Int J Environ Res Public Health 18 2518 (2021)
  8. Impaired synthesis of erythropoietin, glutamine synthetase and metallothionein in the skin of NOD/SCID/gamma(c)(null) and Foxn1 nu/nu mice with misbalanced production of MHC class II complex. Danielyan L, Verleysdonk S, Buadze M, Gleiter CH, Buniatian GH. Neurochem Res 35 899-908 (2010)


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