› 2oj9

X-ray diffraction
2Å resolution

Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor

Released:
DOI: 10.2210/pdb2oj9/pdb
PDB entry 2oj9 coloured by chain, front view.
PDB entry 2oj9 coloured by chain, side view.
PDB entry 2oj9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).
Velaparthi U, Wittman M, Liu P, Stoffan K, Zimmermann K, Sang X, Carboni J, Li A, Attar R, Gottardis M, Greer A, Chang CY, Jacobsen BL, Sack JS, Sun Y, Langley DR, Balasubramanian B, Vyas D
Bioorg Med Chem Lett 17 2317-21 (2007)
PMID: 17317169

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor 1 receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P08069 (Residues: 982-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BMI 1 x BMI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 57.271Å b: 44.289Å c: 65.744Å
α: 90° β: 99.05° γ: 90°
R-values:
R R work R free
0.217 0.214 0.276
Expression system: unidentified baculovirus

Quick links

Citations

1 review citation

Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.
Li et al. (2009)
13 other articles

20 mentions without citation

DOCK 6: Impact of new features and current docking performance.
Allen et al. (2015)
19 more