2oic Summary

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Crystal structure of IRAK4 kinase domain complexed with staurosporine

The structure was published by Kuglstatter, A., Villasenor, A.G., Shaw, D., et al., Song, K.W., Barnett, J.W., and Browner, M.F., in 2007 in a paper entitled "Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of Interleukin-1 receptor-associated kinase 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (160-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 301 95%
B Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (160-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 301 95%
C Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (160-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 301 95%
D Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (160-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 301 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9NWZ3 (160 - 460) Interleukin-1 receptor-associated kinase 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (Q9NWZ3) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B, C, D Protein kinase domainsearch Protein kinase-like domainsearch