2od8 Summary


Structure of a peptide derived from Cdc9 bound to PCNA

The structure was published by Vijayakumar, S., Chapados, B.R., Schmidt, K.H., Kolodner, R.D., Tainer, J.A., and Tomkinson, A.E., in 2007 in a paper entitled "The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Proliferating cell nuclear antigen and DNA ligase I, mitochondrial precursor.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proliferating cell nuclear antigen P15873 (1-258) (PCNA_YEAST)search Saccharomyces cerevisiae S288csearch 99% 258 98%
B DNA ligase I, mitochondrial precursor P04819 (32-53) (DNLI1_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 22 50%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P15873 (1 - 258) Proliferating cell nuclear antigen Saccharomyces cerevisiae
P04819 (32 - 53) DNA ligase I, mitochondrial precursor

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P15873) DNA polymerase processivity factorsearch Proliferating Cell Nuclear Antigensearch PF00705: Proliferating cell nuclear antigen, N-terminal domainsearch, PF02747: Proliferating cell nuclear antigen, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P15873) regulation of DNA replicationsearch DNA repairsearch lagging strand elongationsearch error-free translesion synthesissearch nucleotide-excision repairsearch postreplication repairsearch establishment of mitotic sister chromatid cohesionsearch positive regulation of exodeoxyribonuclease activitysearch cellular response to DNA damage stimulussearch mitotic sister chromatid cohesionsearch chromatin silencing at silent mating-type cassettesearch meiotic mismatch repairsearch DNA replicationsearch mitotic cell cyclesearch chromatin silencing at telomeresearch mismatch repairsearch maintenance of DNA trinucleotide repeatssearch leading strand elongationsearch positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strandssearch DNA polymerase processivity factor activitysearch DNA bindingsearch identical protein bindingsearch protein bindingsearch replication forksearch nucleussearch PCNA complexsearch

Chain InterPro annotation
A Proliferating cell nuclear antigen, PCNAsearch Proliferating cell nuclear antigen, PCNA, N-terminalsearch Proliferating cell nuclear antigen, PCNA, C-terminalsearch Proliferating cell nuclear antigen, PCNA, conserved sitesearch