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Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody

X-ray diffraction
2.95Å resolution
PDB entry 2ocf coloured by chain, front view.
PDB entry 2ocf coloured by chain, side view.
PDB entry 2ocf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibronectin and Estrogen receptor
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Multimeric state: hetero tetramer
Accessible surface area: 28240.54 Å2
Buried surface area: 8626.15 Å2
Dissociation area: 1,677.97 Å2
Dissociation energy (ΔGdiss): 4.82 kcal/mol
Dissociation entropy (TΔSdiss): 13.93 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136143

Macromolecules

Estrogen receptor
Chain: A
Length: 298 amino acids
Theoretical weight: 33.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03372 (Residues: 298-595; Coverage: 50%)
Gene names: ESR, ESR1, NR3A1
Pfam:
InterPro:
CATH: Retinoid X Receptor
Estrogen receptor in PDB entry 2ocf, assembly 1, front view.
Estrogen receptor in PDB entry 2ocf, assembly 1, side view.
Estrogen receptor in PDB entry 2ocf, assembly 1, top view.
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Ugl-Y3
Chain: D
Length: 121 amino acids
Theoretical weight: 13.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02751 (Residues: 1538-1631; Coverage: 4%)
Gene names: FN, FN1
Pfam: Fibronectin type III domain
InterPro:
CATH: Immunoglobulins
Ugl-Y3 in PDB entry 2ocf, assembly 1, front view.
Ugl-Y3 in PDB entry 2ocf, assembly 1, side view.
Ugl-Y3 in PDB entry 2ocf, assembly 1, top view.
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