2obj Summary

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Crystal structure of human PIM-1 Kinase in complex with inhibitor

The structure was published by Cheney, I.W., Yan, S., Appleby, T., et al., Hamatake, R., Hong, Z., and Wu, J.Z., in 2007 in a paper entitled "Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase Pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN)search. The sample contained 333 residues which is < 90% of the natural sequence. Out of 333 residues 273 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene serine/threonine-protein kinase Pim-1 P11309 (92-404) (PIM1_HUMAN)search Homo sapienssearch 100% 333 81%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (92 - 404) Proto-oncogene serine/threonine-protein kinase Pim-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P11309) transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch