2oau Summary

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PDB entry 2oau (supersedes 1mxm)

Mechanosensitive Channel of Small Conductance (MscS)

The structure was published by Steinbacher, S., Bass, R., Strop, P., and Rees, D.C., in 2007 in a paper entitled "Structures of the Prokaryotic Mechanosensitive Channels MscL and MscS" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.7 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Small-conductance mechanosensitive channel.

The molecule most likely forms homoheptamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Small-conductance mechanosensitive channel P0C0S1 (1-286) (MSCS_ECOLI)search Escherichia coli K-12search 100% 306 83%
B Small-conductance mechanosensitive channel P0C0S1 (1-286) (MSCS_ECOLI)search Escherichia coli K-12search 100% 306 83%
C Small-conductance mechanosensitive channel P0C0S1 (1-286) (MSCS_ECOLI)search Escherichia coli K-12search 100% 306 83%
D Small-conductance mechanosensitive channel P0C0S1 (1-286) (MSCS_ECOLI)search Escherichia coli K-12search 100% 306 83%
E Small-conductance mechanosensitive channel P0C0S1 (1-286) (MSCS_ECOLI)search Escherichia coli K-12search 100% 306 83%
F Small-conductance mechanosensitive channel P0C0S1 (1-286) (MSCS_ECOLI)search Escherichia coli K-12search 100% 306 83%
G Small-conductance mechanosensitive channel P0C0S1 (1-286) (MSCS_ECOLI)search Escherichia coli K-12search 100% 306 83%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0C0S1 (1 - 286) Small-conductance mechanosensitive channel Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G (P0C0S1) Mechanosensitive channel protein MscS (YggB), middle domainsearch, Mechanosensitive channel protein MscS (YggB), C-terminal domainsearch, Mechanosensitive channel protein MscS (YggB), transmembrane regionsearch SH3 type barrels.search, Alpha-Beta Plaitssearch PF00924: Mechanosensitive ion channelsearch, PF05552: Conserved TM helixsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D, E, F, G (P0C0S1) membranesearch plasma membranesearch integral component of membranesearch transmembrane transportsearch transportsearch ion transmembrane transportsearch ion transportsearch cellular water homeostasissearch mechanically-gated ion channel activitysearch

Chain InterPro annotation
A, B, C, D, E, F, G Mechanosensitive ion channel MscSsearch Mechanosensitive ion channel MscS, conserved sitesearch Conserved TM helixsearch Like-Sm (LSM) domainsearch Mechanosensitive ion channel MscS, transmembrane-2search Mechanosensitive ion channel MscS, C-terminalsearch