2oat Summary

pdbe.org/2oat
spacer

ORNITHINE AMINOTRANSFERASE COMPLEXED WITH 5-FLUOROMETHYLORNITHINE

The structure was published by Storici, P., Capitani, G., Muller, R., Schirmer, T., and Jansonius, J.N., in 1999 in a paper entitled "Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ORNITHINE AMINOTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ORNITHINE AMINOTRANSFERASE P04181 (1-439) (OAT_HUMAN)search Homo sapienssearch 92% 439 92%
B ORNITHINE AMINOTRANSFERASE P04181 (1-439) (OAT_HUMAN)search Homo sapienssearch 92% 439 92%
C ORNITHINE AMINOTRANSFERASE P04181 (1-439) (OAT_HUMAN)search Homo sapienssearch 92% 439 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04181 (1 - 439) ORNITHINE AMINOTRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C (P04181) GABA-aminotransferase-likesearch Aspartate Aminotransferase, domain 1search, Type I PLP-dependent aspartate aminotransferase-like (Major domain)search PF00202: Aminotransferase class-IIIsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C (P04181) pyridoxal phosphate bindingsearch transaminase activitysearch catalytic activitysearch transferase activitysearch ornithine-oxo-acid transaminase activitysearch mitochondrial matrixsearch mitochondrionsearch visual perceptionsearch cellular nitrogen compound metabolic processsearch small molecule metabolic processsearch cellular amino acid biosynthetic processsearch L-proline biosynthetic processsearch protein hexamerizationsearch

Chain InterPro annotation
A, B, C Aminotransferase class-IIIsearch Ornithine aminotransferasesearch Pyridoxal phosphate-dependent transferase, major region, subdomain 1search Pyridoxal phosphate-dependent transferase, major region, subdomain 2search Pyridoxal phosphate-dependent transferasesearch