2o9v Summary


The second SH3 domain from Ponsin in complex with the paxillin proline rich region

The structure was published by Gehmlich, K., Pinotsis, N., Hayess, K., et al., El Banayosy, A., Wilmanns, M., and Ehler, E., in 2007 in a paper entitled "Paxillin and ponsin interact in nascent costameres of muscle cells" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.63 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Ponsin and Paxillin.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ponsin Q9BX66 (870-930) (SRBS1_HUMAN)search Homo sapienssearch < 90% 67 100%
B Paxillin P49023 (45-54) (PAXI_HUMAN)search Homo sapienssearch < 90% 10 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9BX66 (870 - 930) Ponsin Homo sapiens
P49023 (45 - 54) Paxillin

Chain Structural classification (CATH) Sequence family (Pfam)
A SH3 Domainssearch Variant SH3 domainsearch
B Paxillin familysearch

Chain ID Biological process (GO)
A (Q9BX66) actin filament organizationsearch insulin receptor signaling pathwaysearch

Chain InterPro annotation
A SH3 domainsearch c-Cbl associated proteinsearch