2o9i Summary

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Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317

The structure was published by Xue, Y., Chao, E., Zuercher, W.J., Willson, T.M., Collins, J.L., and Redinbo, M.R., in 2007 in a paper entitled "Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Orphan nuclear receptor PXR and Nuclear Receptor Coactivator 1 isoform 3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Orphan nuclear receptor PXR O75469 (142-434) (NR1I2_HUMAN)search Homo sapienssearch < 90% 293 95%
B Orphan nuclear receptor PXR O75469 (142-434) (NR1I2_HUMAN)search Homo sapienssearch < 90% 293 95%
C Nuclear Receptor Coactivator 1 isoform 3 P70365 (686-700) (NCOA1_MOUSE)search Mus musculussearch < 90% 15 100%
D Nuclear Receptor Coactivator 1 isoform 3 P70365 (686-700) (NCOA1_MOUSE)search Mus musculussearch < 90% 15 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O75469 (142 - 434) Orphan nuclear receptor PXR Homo sapiens
P70365 (686 - 700) Nuclear Receptor Coactivator 1 isoform 3

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (O75469) DNA bindingsearch calcitriol receptor activitysearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch thyroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search Steroid receptor coactivatorsearch