2o4z Summary


Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor

The structure was published by Temperini, C., Winum, J.Y., Montero, J.L., Scozzafava, A., and Supuran, C.T., in 2007 in a paper entitled "Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch apical part of cellsearch extracellular spacesearch myelin sheathsearch cytosolsearch cytoplasmsearch plasma membranesearch extracellular vesicular exosomesearch microvillussearch basolateral plasma membranesearch axonsearch membranesearch cellular response to fluid shear stresssearch positive regulation of bone resorptionsearch regulation of anion transportsearch regulation of intracellular pHsearch bicarbonate transportsearch response to estrogensearch response to steroid hormonesearch angiotensin-activated signaling pathwaysearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch regulation of chloride transportsearch kidney developmentsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch secretionsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch small molecule metabolic processsearch one-carbon metabolic processsearch response to zinc ionsearch response to pHsearch morphogenesis of an epitheliumsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch