2nzi Summary

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Crystal structure of domains A168-A170 from titin

The structure was published by Mrosek, M., Labeit, D., Witt, S., et al., von Castelmur, E., Labeit, S., and Mayans, O., in 2007 in a paper entitled "Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Titin.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Titin Q8WZ42 (31854-32155) (TITIN_HUMAN)search Homo sapienssearch < 90% 305 95%
B Titin Q8WZ42 (31854-32155) (TITIN_HUMAN)search Homo sapienssearch < 90% 305 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8WZ42 (31854 - 32155) Titin Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Immunoglobulinssearch Fibronectin type III domainsearch, Immunoglobulin I-set domainsearch
Chain InterPro annotation
A, B Immunoglobulin subtypesearch Fibronectin type IIIsearch Immunoglobulin-like domainsearch Immunoglobulin I-setsearch Immunoglobulin-like foldsearch