PDBe Entry: 2nyl

Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated

Summary

Header

HYDROLASE

Method

X-RAY DIFFRACTION

Experiment

Resolution: 3.8 Å, R-factor: 32.0%, Free R-factor: 33.5%, Spacegroup: P 21 21 21

Released

12/12/2006, deposition: 20/11/2006, last revision: 24/02/2009

Authors

Xing, Y.

; Xu, Y.

; Chen, Y.

; Chao, Y.

; Lin, Z.

; Shi, Y.

Primary citation

Structure of the Protein Phosphatase 2A Holoenzyme.
CELL(CAMBRIDGE,MASS.)

vol:127, pag:1239-1251 (2006) [PubMed ID 17174897 ]

Keywords

HEAT repeat

, HYDROLASE

3.1.3.16 ExPASy BRENDA

(C F)

Organism

Homo sapiens(human) 9606

(A D B E C F)

UniProt

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein) P30153

(A D)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (Renal carcinoma antigen NY-REN-29) Q13362

(B E)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (EC 3.1.3.16) (PP2A-alpha) (Replication protein C) (RP-C) P67775

(C F)

Related entries

2npp, 2ie3, 2ie4, 2nym

Polymers

Id	Name	Type	UniProt	Residues	Observed
A, D	Protein phosphatase 2, regulatory subunit A (PR 65), alpha isoform	Protein	P30153 (2AAA_HUMAN)	582	100%
B, E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	Protein	Q13362 (2A5G_HUMAN)	388	100%
C, F	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	Protein	P67775 (PP2AA_HUMAN)	293	100%
G, H	C-terminal truncated catalytic subunit	Protein		7	100%

Heterogens

Id	Name	Ligands
C, F	MANGANESE (II) ION	MN