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PDBe Entry: 2ny3 view

HIV-1 gp120 Envelope Glycoprotein (K231C, T257S, E267C, S334A, S375W) Complexed with CD4 and Antibody 17b
Summary
Header VIRAL PROTEIN/IMMUNE SYSTEMsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.0 Å, R-factor: 20.513%, Free R-factor: 24.284%, Spacegroup: P 2 2 21
Released 06/02/2007, deposition: 20/11/2006, last revision: 24/02/2009
Authors Zhou, T.search; Xu, L.search; Dey, B.search; Hessell, A.J.search; Van Ryk, D.search; Xiang, S.H.search; Yang, X.search; Zhang, M.Y.search; Zwick, M.B.search; Arthos, J.search; Burton, D.R.search; Dimitrov, D.S.search; Sodroski, J.search; Wyatt, R.search; Nabel, G.J.search; Kwong, P.D.search
Primary citation Structural definition of a conserved neutralization epitope on HIV-1 gp120.
NATUREsearch vol:445, pag:732-737 (2007) [PubMed ID 17301785 ]search
Keywords HIVsearch, gp120search, antibodysearch, CD4search, VIRAL PROTEIN/IMMUNE SYSTEM COMPLEXsearch
Organism Human immunodeficiency virus 1 11676search(A),Homo sapiens(human) 9606search(B C D)
UniProt Envelope glycoprotein (Fragment) Q993A8search (A)
T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) P01730search (B)
IGK@ protein Q6P5S8search (C)
Putative uncharacterized protein DKFZp686I15212 Q6N030search (D)
Solvent A, B, C, D
Related entries 1gc1, 1rzj, 1rzk, 2nxy, 2nxz, 2ny0, 2ny1, 2ny2, 2ny4, 2ny5, 2ny6, 2ny7
Polymers
Id Name Type UniProt Residues Observed
A ENVELOPE GLYCOPROTEIN GP120 Protein Q993A8 (Q993A8_9HIV1)search
317 96%
B T-cell surface glycoprotein CD4 Protein P01730 (CD4_HUMAN)search
184 98%
C ANTIBODY 17B, LIGHT CHAIN Protein Q6P5S8 (Q6P5S8_HUMAN)search
214 100%
D ANTIBODY 17B, HEAVY CHAIN Protein Q6N030 (Q6N030_HUMAN)search
229 97%
Heterogens
Id Name Ligands
A SUGAR (N-ACETYL-D-GLUCOSAMINE) NAG search
D SUGAR (SUCROSE) SUC search
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