2nxx Summary

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Crystal Structure of the Ligand-Binding Domains of the T.castaneum (Coleoptera) Heterodimer EcrUSP Bound to Ponasterone A

The structure was published by Iwema, T., Billas, I.M., Beck, Y., et al., Richards, G., Laudet, V., and Moras, D., in 2007 in a paper entitled "Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Ultraspiracle (USP, NR2B4) and Ecdysone Receptor (EcR, NRH1).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ultraspiracle (USP, NR2B4) A1JUG2 (174-407) (A1JUG2_TRICA)search Tribolium castaneumsearch < 90% 235 97%
B Ultraspiracle (USP, NR2B4) A1JUG2 (174-407) (A1JUG2_TRICA)search Tribolium castaneumsearch < 90% 235 97%
C Ultraspiracle (USP, NR2B4) A1JUG2 (174-407) (A1JUG2_TRICA)search Tribolium castaneumsearch < 90% 235 97%
D Ultraspiracle (USP, NR2B4) A1JUG2 (174-407) (A1JUG2_TRICA)search Tribolium castaneumsearch < 90% 235 97%
E Ecdysone Receptor (EcR, NRH1) A1JUG3 (306-549) (A1JUG3_TRICA)search Tribolium castaneumsearch < 90% 248 94%
F Ecdysone Receptor (EcR, NRH1) A1JUG3 (306-549) (A1JUG3_TRICA)search Tribolium castaneumsearch < 90% 248 94%
G Ecdysone Receptor (EcR, NRH1) A1JUG3 (306-549) (A1JUG3_TRICA)search Tribolium castaneumsearch < 90% 248 94%
H Ecdysone Receptor (EcR, NRH1) A1JUG3 (306-549) (A1JUG3_TRICA)search Tribolium castaneumsearch < 90% 248 94%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
A1JUG2 (174 - 407) Ultraspiracle (USP, NR2B4) Tribolium castaneum
A1JUG3 (306 - 549) Ecdysone Receptor (EcR, NRH1) Tribolium castaneum

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
E, F, G, H Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (A1JUG2) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch zinc ion bindingsearch steroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch
E, F, G, H (A1JUG3) steroid hormone receptor activitysearch DNA bindingsearch steroid bindingsearch sequence-specific DNA binding transcription factor activitysearch ecdysteroid hormone receptor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch ecdysone receptor-mediated signaling pathwaysearch

Chain InterPro annotation
A, B, C, D Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
E, F, G, H Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Ecdysteroid receptorsearch Nuclear hormone receptor, ligand-bindingsearch