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EBI PDBe PDBeView

PDBe Entry: 2nxg view

Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase.
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.95 Å, R-factor: 20.9%, Free R-factor: 24.3%, Spacegroup: P 31 2 1
Released 24/04/2007, deposition: 17/11/2006, last revision: 24/02/2009
Authors Kona, F.search; Xu, X.search; Martin, P.search; Kuzmic, P.search; Gatti, D.L.search
Primary citation Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
BIOCHEMISTRYsearch vol:46, pag:4532-4544 (2007) [PubMed ID 17381075 ]search
Keywords KDOsearch, KDO8Psearch, KDO8PSsearch, PEPsearch, A5Psearch, TRANSFERASEsearch
EC 2.5.1.55 ExPASy BRENDA search (A B)
Organism Aquifex aeolicus 63363search(A B)
UniProt 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (Phospho-2-dehydro-3-deoxyoctonate aldolase) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase) (KDO-8-phosphate synthetase) (KDO 8-P synthase) (KDOPS) O66496search (A B)
Solvent A, B
Related entries 2nxh, 2nxi, 2nxk
Polymers
Id Name Type UniProt Residues Observed
A, B 2-dehydro-3-deoxyphosphooctonate aldolase Protein O66496 (KDSA_AQUAE)search
 263 100%
Heterogens
Id Name Ligands
A PHOSPHOENOLPYRUVATE PEP search
A ARABINOSE-5-PHOSPHATE A5P search
B (2R,4R,5R,6R,7R)-2,4,5,6,7-PENTAHYDROXY-2,8-BIS(PHOSPHONOOXY)OCTANOIC ACID 1NT search
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