› 2nry

X-ray diffraction
2.15Å resolution

Crystal structure of IRAK-4

Released:
DOI: 10.2210/pdb2nry/pdb
PDB entry 2nry coloured by chain, front view.
PDB entry 2nry coloured by chain, side view.
PDB entry 2nry coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.
Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP
Structure 14 1835-44 (2006)
PMID: 17161373

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 307 amino acids
Theoretical weight: 34.5 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9NWZ3 (Residues: 154-460; Coverage: 67%)
Gene name: IRAK4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand STU 4 x STU
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 141.502Å b: 139.748Å c: 87.656Å
α: 90° β: 123.76° γ: 90°
R-values:
R R work R free
0.212 0.209 0.26
Expression system: unidentified baculovirus

Quick links

Citations

15 review citations

Targeting innate immunity protein kinase signalling in inflammation.
Gaestel et al. (2009)
14 more

13 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
12 more