2nru Summary

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Crystal structure of IRAK-4

The structure was published by Wang, Z., Liu, J., Sudom, A., et al., Wesche, H., Powers, J.P., and Walker, N.P.C., in 2006 in a paper entitled "Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Interleukin-1 receptor-associated kinase 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (154-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 307 96%
B Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (154-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 307 96%
C Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (154-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 307 96%
D Interleukin-1 receptor-associated kinase 4 Q9NWZ3 (154-460) (IRAK4_HUMAN)search Homo sapienssearch < 90% 307 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9NWZ3 (154 - 460) Interleukin-1 receptor-associated kinase 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D (Q9NWZ3) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch

Chain InterPro annotation
A, B, C, D Protein kinase domainsearch Protein kinase-like domainsearch