2nqd Summary


Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L

The structure was published by Ljunggren, A., Redzynia, I., Alvarez-Fernandez, M., et al., Krupa, J.C., Jaskolski, M., and Bujacz, G., in 2007 in a paper entitled "Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Chagasin and Cathepsin L.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Chagasin Q966X9 (2-110) (CHAG_TRYCR)search Trypanosoma cruzisearch 99% 109 100%
B Cathepsin L P07711 (113-333) (CATL1_HUMAN)search Homo sapienssearch 99% 221 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q966X9 (2 - 110) Chagasin Trypanosoma cruzi
P07711 (113 - 333) Cathepsin L Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q966X9) ICP-likesearch PF09394: Chagasin family peptidase inhibitor I42search
B (P07711) Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q966X9) ciliary pocketsearch cell surfacesearch cytoplasmic vesiclesearch cytoplasmic membrane-bounded vesiclesearch negative regulation of peptidase activitysearch negative regulation of endopeptidase activitysearch peptidase inhibitor activitysearch cysteine-type endopeptidase inhibitor activitysearch
B (P07711) proteolysissearch cysteine-type peptidase activitysearch

Chain InterPro annotation
A Proteinase inhibitor I42, chagasinsearch
B Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch