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Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L

Source organisms:
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: cytoplasmic vesicle

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EC 3.4.22.15: Cathepsin L

Reaction catalysed:
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Systematic name:
-
Alternative Name(s):
  • Aldrichina grahami cysteine proteinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin L
The deposited structure of PDB entry 2nqd contains 1 copy of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin L. Showing 1 copy in chain B.

PF09394
Domain description: Chagasin family peptidase inhibitor I42
Occurring in:
  1. Chagasin
The deposited structure of PDB entry 2nqd contains 1 copy of Pfam domain PF09394 (Chagasin family peptidase inhibitor I42) in Chagasin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin L
IPR036331
Domain description: Chagasin-like superfamily
Occurring in:
  1. Chagasin
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin L
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin L
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin L
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Cathepsin L
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin L
IPR018990
Domain description: Proteinase inhibitor I42, chagasin
Occurring in:
  1. Chagasin

Structure domains

CATH CATH domains
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cathepsin L
The deposited structure of PDB entry 2nqd contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cathepsin L. Showing 1 copy in chain B.
2.60.40.2020
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Chagasin
The deposited structure of PDB entry 2nqd contains 1 copy of CATH domain 2.60.40.2020 (Immunoglobulin-like) in Chagasin. Showing 1 copy in chain A.
SCOP SCOP annotation
141067
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: ICP-like
Occurring in:
  1. Chagasin
The deposited structure of PDB entry 2nqd contains 1 copy of SCOP domain 141067 (ICP-like) in Chagasin. Showing 1 copy in chain A.

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