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The solution structure of the rapamycin-binding domain of mTOR (FRB)

Solution NMR
PDB entry 2npu coloured by chain, ensemble of 32 models, front view.
PDB entry 2npu coloured by chain, ensemble of 32 models, side view.
PDB entry 2npu coloured by chain, ensemble of 32 models, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase mTOR
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Multimeric state: monomeric
Accessible surface area: 7180.08 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154617

Macromolecules

Serine/threonine-protein kinase mTOR
Chain: A
Length: 126 amino acids
Theoretical weight: 15.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42345 (Residues: 2015-2114; Coverage: 4%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Pfam: FKBP12-rapamycin binding domain
InterPro:
CATH: FKBP12-rapamycin binding domain
Serine/threonine-protein kinase mTOR in PDB entry 2npu, assembly 1, front view.
Serine/threonine-protein kinase mTOR in PDB entry 2npu, assembly 1, side view.
Serine/threonine-protein kinase mTOR in PDB entry 2npu, assembly 1, top view.
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