2nnv Summary


Structure of inhibitor binding to Carbonic Anhydrase II

The structure was published by Srivastava, D.K., Jude, K.M., Banerjee, A.L., et al., Kooren, J., Mallik, S., and Christianson, D.W., in 2007 in a paper entitled "Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.1 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch carbon dioxide transportsearch bicarbonate transportsearch secretionsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch response to estrogensearch response to pHsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch response to organic substancesearch kidney developmentsearch regulation of intracellular pHsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch extracellular spacesearch cytoplasmsearch plasma membranesearch cytosolsearch extracellular vesicular exosomesearch axonsearch membranesearch apical part of cellsearch microvillussearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch