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PDBe Entry: 2nnj 
CYP2C8dH complexed with felodipine
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OXIDOREDUCTASE,ELECTRON TRANSPORT
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X-RAY DIFFRACTION
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Resolution: 2.28 Å, R-factor: 24.0%, Free R-factor: 27.0%, Spacegroup: I 2 2 2
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23/10/2007, deposition: 24/10/2006, last revision: 09/06/2009
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Schoch, G.A.; Yano, J.K.; Stout, C.D.; Johnson, E.F.
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Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.BIOL.CHEM. vol:283, pag:17227-17237 (2008) [PubMed ID 18413310 ]
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CYP2C8; Human P450 2C8; monooxygenases; Felodipine; Plendil; inhibitor complex; palmitic acid, OXIDOREDUCTASE, ELECTRON TRANSPORT
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1.14.14.1 ExPASy BRENDA (A)
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Homo sapiens(human) 9606(A)
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Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP-12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase) P10632 (A)
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A
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2nnh, 2nni
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| A |
Cytochrome P450 2C8 |
Protein |
P10632 (CP2C8_HUMAN)
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476 |
97% |
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| A |
SULFATE ION |
SO4
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| A |
PROTOPORPHYRIN IX CONTAINING FE |
HEM
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| A |
FELODIPINE |
225
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| A |
PALMITIC ACID |
PLM
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