2nn7 Summary

pdbe.org/2nn7
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Structure of inhibitor binding to Carbonic Anhydrase I

The structure was published by Srivastava, D.K., Jude, K.M., Banerjee, A.L., et al., Kooren, J., Mallik, S., and Christianson, D.W., in 2007 in a paper entitled "Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Carbonic anhydrase 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 1 P00915 (2-261) (CAH1_HUMAN)search Homo sapienssearch 98% 260 99%
B Carbonic anhydrase 1 P00915 (2-261) (CAH1_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00915 (2 - 261) Carbonic anhydrase 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00915) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P00915) cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch bicarbonate transportsearch one-carbon metabolic processsearch small molecule metabolic processsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA1search Carbonic anhydrase, alpha-classsearch