2nn6 Summary


Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40

The structure was published by Liu, Q., Greimann, J.C., and Lima, C.D., in 2006 in a paper entitled "Reconstitution, activities, and structure of the eukaryotic RNA exosome." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.35 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This entry contains 9 copies of 9 unique biopolymers (complete list).

The molecule most likely forms heterononamer.

The are more than 5 unique protein polymers in this entry. More information is available on the Uniprot cross references page.

This entry contains 9 unique UniProt proteins:

UniProt accession Name Organism PDB
Q06265 (1 - 302) Polymyositis/scleroderma autoantigen 1 Homo sapiens
Q9NPD3 (2 - 245) Exosome complex exonuclease RRP41 Homo sapiens
Q96B26 (1 - 276) Exosome complex exonuclease RRP43 Homo sapiens
Q9NQT4 (1 - 235) Exosome complex exonuclease RRP46 Homo sapiens
Q15024 (1 - 291) Exosome complex exonuclease RRP42 Homo sapiens
Q5RKV6 (1 - 272) Exosome component 6 Homo sapiens
Q9NQT5 (1 - 275) Exosome complex exonuclease RRP40 Homo sapiens
Q13868 (1 - 293) Exosome complex exonuclease RRP4 Homo sapiens
Q9Y3B2 (1 - 195) 3'-5' exoribonuclease CSL4 homolog Homo sapiens

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